Performance of Tencate Mirafi PGM-G4 Interlayer-Reinforced Asphalt Pavements in Alaska

Geosynthetics has been used in hot mix asphalt (HMA) overlays in a variety of design and construction situations for more than three decades. A number of positive benefits have been identified such as waterproofing control for base and subgrade protection, improved fatigue resistance and reduced propagation of reflective cracks. In cold regions such as Alaska and other northern states, pavements are more prone to distresses due to extreme climatic conditions. Research is needed to explore how interlayers functions in asphalt pavements in cold regions. The interlayers used for pavement reinforcement applications and available in the market are primarily biaxial. Biaxial grids with equal strength in both the machine and cross machine directions allow stress transfer at low strain mainly in longitudinal and transverse directions. The new PGM-G4 paving composite developed by Tencate Geosynthetics contains multi-axial fiberglass filament yarn, which changes the aperture geometry from a rectangular to a quad angular grid structure. This unique feature improves the structure radial stiffness and efficiently distributes stress from surface layer to the geogrid throughout the full 360o. This isotropic feature could deliver optimal asphalt concrete (AC)/grid interaction and more efficient reinforcement. There is a need to identify/validate its expected performance and added value over conventional biaxial grids. Hence, a study has been conducted on interlayer-reinforced asphalt pavements in Alaska that included two phases: laboratory index testing (Phase I) and field performance evaluation (Phase II). Phase I focused on laboratory evaluation of engineering properties of PGM-G4 composite paving grid-reinforced asphalt pavement structure and comparison with other types of interlayers. Five types of interlayers were evaluated in this study for various laboratory tests and they were PGM-G4 (multi-axial composite grid), PGM-G100/100 and PGM-G50/50 (bi-axial composite grid), TruPave® (engineered paving fiberglass and polyester hybrid mat), and MPV500 (conventional polypropylene interlayer). The performance tests included asphalt retention and grab strength tests of interlayers, and shear strength, permeability and indirect tension (IDT) tests of interlayer-reinforced asphalt mixtures. Further, a typical Alaska flexible pavement structure was used, and pavement structure analyses and simulation were conducted by Bisar, Alaska Flexible Pavement Design (AKFPD) and ABAQUS programs to investigate the effects of paving interlayers on the pavement performance.Tencate Geosynthetics North Americ

NASA Earth Observations Informing Energy Management Decision Making

The Energy Sector is experiencing increasing impacts from severe weather and shifting climatic trends, as well as facing a changing political climate, adding uncertainty for stakeholders as they make short- and long-term planning investments. Climate changes such as prolonged extreme heat and drought (leading to wildfire spread, for example), sea level rise, and extreme storms are changing the ways that utilities operate. Energy infrastructure located in coastal or flood-prone areas faces inundation risks, such as damage to energy facilities. The use of renewable energy resources is increasing, requiring more information about their intermittency and spatial patterns. In light of these challenges, public and private stakeholders have collaborated to identify potential data sources, tools, and programmatic ideas. For example, utilities across the country are using cutting-edge technology and data to plan for and adapt to these changes. In the Federal Government, NASA has invested in preliminary work to identify needs and opportunities for satellite data in energy sector application, and the Department of Energy has similarly brought together stakeholders to understand the landscape of climate vulnerability and resilience for utilities and others. However, have these efforts improved community-scale resilience and adaptation efforts? Further, some communities are more vulnerable to climate change and infrastructure impacts than others. This session has two goals. First, panelists seek to share existing and ongoing efforts related to energy management. Second, the session seeks to engage with attendees via group knowledge exchange to connect national energy management efforts to local practice for increased community resilience

Assessment of ridden horse behavior

Assessments of the behavior of ridden horses form the basis of performance evaluation. The purpose of any performance being evaluated will determine the factors considered important, those indicative of 'poor' performance and what makes a successful equine athlete. Currently there is no consistent objective means of assessing ridden horse behavior and inevitably, given the different equestrian disciplines, the likelihood of a universal standard of good and bad performance is remote. Nevertheless, in order to protect the welfare of the ridden horse regardless of its specific role, we should strive for consensus on an objective means of identifying behavioral signs indicative of mental state. Current technological developments enable objective evaluation of movement patterns, but many aspects of the assessment of ridden behavior still rely on subjective judgement. The development of a list of behaviors exhibited by ridden horses, a ridden horse ethogram, will facilitate recording of observable behavioral events. However, without objective evidence of the relevance of these behavioral events, such a resource has limited value

A randomised comparison of deferasirox versus deferoxamine for the treatment of transfusional iron overload in sickle cell disease

Deferasirox is a once-daily, oral iron chelator developed for treating transfusional iron overload. Preclinical studies indicated that the kidney was a potential target organ of toxicity. As patients with sickle cell disease often have abnormal baseline renal function, the primary objective of this randomised, open-label, phase II trial was to evaluate the safety and tolerability of deferasirox in comparison with deferoxamine in this population. Assessment of efficacy, as measured by change in liver iron concentration (LIC) using biosusceptometry, was a secondary objective. A total of 195 adult and paediatric patients received deferasirox (n = 132) or deferoxamine (n = 63). Adverse events most commonly associated with deferasirox were mild, including transient nausea, vomiting, diarrhoea, abdominal pain and skin rash. Abnormal laboratory studies with deferasirox were occasionally associated with mild non-progressive increases in serum creatinine and reversible elevations in liver function tests. Discontinuation rates from deferasirox (11·4%) and deferoxamine (11·1%) were similar. Over 1 year, similar dose-dependent LIC reductions were observed with deferasirox and deferoxamine. Once-daily oral deferasirox has acceptable tolerability and appears to have similar efficacy to deferoxamine in reducing iron burden in transfused patients with sickle cell disease

Hydroxyurea and sickle cell anemia: effect on quality of life

BACKGROUND: The Multicenter Study of Hydroxyurea (HU) in Sickle Cell Anemia (MSH) previously showed that daily oral HU reduces painful sickle cell (SS) crises by 50% in patients with moderate to severe disease. The morbidity associated with this disease is known to have serious negative impact on the overall quality of life(QOL) of affected individuals. METHODS: The data in this report were collected from the 299 patients enrolled in the MSH. Health quality of llife (HQOL) measures were assessed in the MSH as a secondary endpoint to determine if the clinical benefit of HU could translate into a measurable benefit perceptible to the patients. HQOL was assessed with the Profile of Mood States, the Health Status Short Form 36 (SF-36), including 4-week pain recall, and the Ladder of Life, self-administered twice 2-weeks apart pre-treatment and every 6 months during the two-year, randomized, double-blind, treatment phase. The effects of factors including randomized treatment, age, gender, pre-treatment crises frequency, Hb-F level mean, daily pain from 4-week pre-treatment diaries, and 2-year Hb-F response level (low or high) were investigated. RESULTS: Over two years of treatment, the benefit of HU treatment on QOL, other than pain scales, was limited to those patients taking HU who maintained a high HbF response, compared to those with low HbF response or on placebo. These restricted benefits occurred in social function, pain recall and general health perception. Stratification according to average daily pain prior to treatment showed that responders to HU whose average daily pain score was 5–9 (substantial pain) achieved significant reduction in the tension scale compared to the placebo group and to non-responders. HU had no apparent effect on other QOL measures. CONCLUSION: Treatment of SS with HU improves some aspects of QOL in adult patients who already suffer from moderate-to-severe SS

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment